A novel EIF3C-related CD8⁺ T-cell signature in predicting prognosis and immunotherapy response of nasopharyngeal carcinoma.

ABSTRACT:

Purpose

At present, dysfunctional CD8⁺ T-cells in the nasopharyngeal carcinoma (NPC) tumor immune microenvironment (TIME) have caused unsatisfactory immunotherapeutic effects, such as a low response rate of anti-PD-L1 therapy. Therefore, there is an urgent need to identify reliable markers capable of accurately predicting immunotherapy efficacy.

Methods

Utilizing various algorithms for immune-infiltration evaluation, we explored the role of EIF3C in the TIME. We next found the influence of EIF3C expression on NPC based on functional analyses and RNA sequencing. By performing correlation and univariate Cox analyses of CD8⁺ Tcell markers from scRNA-seq data, we identified four signatures, which were then used in conjunction with the lasso algorithm to det

SUBMITTER: Li R 

PROVIDER: S-EPMC10894114 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature