A systematic review and meta-analysis of circulating adhesion molecules in rheumatoid arthritis.

ABSTRACT:

Background

The availability of robust biomarkers of endothelial activation might enhance the identification of subclinical atherosclerosis in rheumatoid arthritis (RA). We investigated this issue by conducting a systematic review and meta-analysis of cell adhesion molecules in RA patients.

Methods

We searched electronic databases from inception to 31 July 2023 for case-control studies assessing the circulating concentrations of immunoglobulin-like adhesion molecules (vascular cell, VCAM-1, intercellular, ICAM-1, and platelet endothelial cell, PECAM-1, adhesion molecule-1) and selectins (E, L, and P selectin) in RA patients and healthy controls. Risk of bias and certainty of evidence were assessed using the JBI checklist and GRADE, respectively.

Results

In 39 studies,

SUBMITTER: Mangoni AA 

PROVIDER: S-EPMC10894129 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature