Validation of the interaction between PRDX4 and TXNDC5 in gastric cancer and the significance of the PRDX4 gene in gastric cancer based on a data mining analysis.

ABSTRACT:

Background

We successfully screened the important interacting protein peroxiredoxin 4 (PRDX4) of thioredoxin domain-containing protein 5 (TXNDC5) in gastric cancer. However, its specific molecular mechanism in gastric cancer remains unclear. This study aimed to verify the interaction between PRDX4 and TXNDC5 protein molecules in gastric cancer and analyze the expression and functional significance of PRDX4 in gastric cancer using bioinformatics methods.

Methods

The interaction between TXNDC5 and PRDX4 was verified by the coimmunoprecipitation (co-IP) of the total protein of gastric cancer cells, and tissues with high expressions of TXNDC5. The Human Protein Atlas (HPA) database, UCSC Xena (University of California Santa Cruz xenabrowser) platform, the Kaplan-Meier Plotter pl

SUBMITTER: Zhang L 

PROVIDER: S-EPMC10894329 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature