Preparation of hepatocellular carcinoma mRNA vaccines based on potential tumor targets and immunophenotypes.

ABSTRACT:

Background

With the development of messenger RNA (mRNA)-based therapeutics for malignant tumor, mRNA vaccines have shown considerable promise for tumor immunotherapy. Immunophenotypes can reflect the tumor microenvironment, which might have a significant influence on the effect of immunotherapy. This study seeks to discover and validate effective antigens that can be employed to develop mRNA vaccines for hepatocellular carcinoma (HCC) and to construct immunophenotypes and immune landscapes to identify potential beneficiaries.

Methods

RNA sequencing (RNASeq) data, mutation information, and clinical information were obtained from HCC patients and control cases from The Cancer Genome Atlas - Liver Hepatocellular Carcinoma (TCGA-LIHC), International Cancer Genome Consortium - Li

SUBMITTER: Wang HK 

PROVIDER: S-EPMC10894330 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature