Comprehensive analysis of m6A RNA methylation regulators in esophageal carcinoma.

ABSTRACT:

Background

N6-methyladenosine (m6A) is the most pervasive modification of RNA methylation in eukaryotic cells. m6A modification plays a pivotal role in tumorigenesis and progression in many types of cancers. Until now, the role of m6A modification in esophageal carcinoma (ESCA) has remained obscure. The aim of the study was to construct and validate prognostic signatures based on m6A regulators for ESCA.

Methods

Transcriptomic data, somatic mutations and clinical information were obtained from The Cancer Genome Atlas (TCGA). Copy number variations were obtained from the UCSC (University of California, Santa Cruz) Xena database. We curated 21 m6A regulators and performed consensus clustering analysis to quantify the m6A modification pattern.

Results

Of the 184 patients

SUBMITTER: Yang H 

PROVIDER: S-EPMC10894331 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature