Identification of C4BPA as biomarker associated with immune infiltration and prognosis in breast cancer.

ABSTRACT:

Background

C4BPA is a gene that encodes the C4BP protein α chain and is involved in the complement system. C4BPA is regarded as a new biomarker for cancer, especially for non-small cell lung cancer and ovarian cancer. However, its role in breast cancer (BC) has not yet been determined.

Methods

In this research, we used a bioinformatics approach to assess the prognostic significance of C4BPA in BC. Utilizing a variety of databases and analysis tools, including The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), R, STRING, and the Kaplan-Meier plotter, we specifically assessed the connection between C4BPA and BC.

Results

C4BPA expression was markedly decreased in BC t

SUBMITTER: Zou J 

PROVIDER: S-EPMC10894332 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature