Complement and coagulation cascades are associated with prognosis and the immune microenvironment of lower-grade glioma.

ABSTRACT:

Background

Abnormal coagulation is a common feature of glioma. There is a strong correlation between coagulation and the complement system, named complement and coagulation cascades (CCC). However, the role of CCC genes in lower-grade glioma (LGG) remains unclear. This study aimed to investigate the role of CCC genes in LGG.

Methods

In total, 5,628 differential expressed genes were identified between 498 LGG tissues from The Cancer Genome Atlas (TCGA) and 207 normal brain tissues from Genotype-Tissue Expression Project (GTEx). Among them, 20 overlapped CCC genes were identified as differentially expressed CCC genes. Then, comprehensive bioinformatics analysis was used to investigate the role of CCC genes in LGG; 271 LGG tissues from the Chinese Glioma Genome Atlas (CGGA) wer

SUBMITTER: Yang J 

PROVIDER: S-EPMC10894340 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature