Association between regulatory T cells and ischemic heart disease: a Mendelian randomization study.

ABSTRACT:

Background

An imbalance of innate and acquired immune responses is significantly involved in the pathophysiology of coronary atherosclerosis and the occurrence of ischemic heart disease (IHD). Regulatory T cells (Tregs) play an essential regulatory role in atherosclerotic plaque formation and maintenance; therefore, dysfunction of Tregs triggers the formation of atherosclerotic plaques and accelerates their progression. However, due to the inherent limitations of observational research, clinical evidence is limited concerning the relationship between the variation in peripheral Tregs and the risk of IHD, and the cause-and-effect relationship between these factors is unclear. Mendelian randomization (MR) uses genetic variation as a proxy for exposure and can be used to inferentially

SUBMITTER: Hou Y 

PROVIDER: S-EPMC10894418 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature