FFAR2 expressing myeloid-derived suppressor cells drive cancer immunoevasion.

ABSTRACT:

Background

Emerging evidences suggest that aberrant metabolites contributes to the immunosuppressive microenvironment that leads to cancer immune evasion. Among tumor immunosuppressive cells, myeloid-derived suppressor cells (MDSCs) are pathologically activated and extremely immunosuppressive, which are closely associated with poor clinical outcomes of cancer patients. However, the correlation between MDSCs mediated immunosuppression and particular cancer metabolism remained elusive.

Methods

Spontaneous lung adenocarcinoma and subcutaneous mouse tumor models, gas chromatography-mass spectrometry (GC-MS) and immunofluorescence assay of patient-derived lung adenocarcinoma tissues, and flow cytometry, RNA sequencing and Western blotting of immune cells, were utilized.

Result

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC10894476 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature