RNA Analysis of Circulating Leukocytes in Patients with Alzheimer's Disease.

ABSTRACT:

Background

One of the key symptoms of Alzheimer's disease (AD) is the impairment of short-term memory. Hippocampal neurogenesis is essential for short-term memory and is known to decrease in patients with AD. Impaired short-term memory and impaired neurogenesis are observed in aged mice alongside changes in RNA expression of gap junction and metabolism-related genes in circulating leukocytes. Moreover, after penetrating the blood-brain barrier via the SDF1/CXCR4 axis, circulating leukocytes directly interact with hippocampal neuronal stem cells via gap junctions.

Objective

Evaluation of RNA expression profiles in circulating leukocytes in patients with AD.

Methods

Patients with AD (MMSE≧23, n = 10) and age-matched controls (MMSE≧28, n = 10) were enrolled into this stu

SUBMITTER: Okinaka Y 

PROVIDER: S-EPMC10894574 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature