Causal Relationship Between Ferritin and Neuropsychiatric Disorders: A Two-Sample Mendelian Randomization Study.

ABSTRACT:

Background

Previous observational research has indicated a correlation between ferritin levels and neuropsychiatric disorders, although the causal relationship remains uncertain.

Objective

The objective of this study was to investigate the potential causal link between plasma ferritin levels and neuropsychiatric disorders.

Methods

A two-sample Mendelian randomization (MR) study was conducted, wherein genetic instruments associated with ferritin were obtained from a previously published genome-wide association study (GWAS). Summary statistics pertaining to neuropsychiatric disorders were derived from five distinct GWAS datasets. The primary MR analysis employed the inverse variance weighted (IVW) method and was corroborated by additional methods including MR-Egger, wei

SUBMITTER: Sun W 

PROVIDER: S-EPMC10894605 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature