Improvement of hedonic perception of odors as a marker of treatment response to Escitalopram - Olfactory changes through an open-label antidepressant trial.

ABSTRACT: The aim of this study is to assess olfactory functions (Threshold, identification and hedonic valence) of depressed subjects before and after an 8-week Escitalopram trial, and compare the results of responders and non-responders to antidepressant. Fifty-two depressed subjects were recruited. Participants received Escitalopram with two evaluation visits, at baseline (V0) and at week 8 (V8). They were categorized as responders (MADRS score reduction of >50%) and non-responders to treatment. Participants were evaluated with the MINI at V0 and had at V0 and V8 psychometric and olfactory assessments, including MADRS and STAI scales, and the "Sniffin' sticks" for threshold and identification tests. The hedonic valence of smell was assessed on a 10 cm linear scale after presenting 2 pleasant and

SUBMITTER: Kazour F 

PROVIDER: S-EPMC10894631 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature