K_V7 but not dual small and intermediate K_Ca channel openers inhibit the activation of colonic afferents by noxious stimuli.

ABSTRACT: In numerous subtypes of central and peripheral neurons, small and intermediate conductance Ca²⁺-activated K⁺ (SK and IK, respectively) channels are important regulators of neuronal excitability. Transcripts encoding SK channel subunits, as well as the closely related IK subunit, are coexpressed in the soma of colonic afferent neurons with receptors for the algogenic mediators ATP and bradykinin, P2X3 and B₂, highlighting the potential utility of these channels as drug targets for the treatment of abdominal pain in gastrointestinal diseases such as irritable bowel syndrome. Despite this, pretreatment with the dual SK/IK channel opener SKA-31 had no effect on the colonic afferent response to ATP, bradykinin, or noxious ramp distention of the colon. Inhibition

SUBMITTER: Bhebhe CN 

PROVIDER: S-EPMC10894664 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature