Association between intravenous fluid administration and endothelial glycocalyx shedding in humans: a systematic review.

ABSTRACT:

Introduction

Several studies have demonstrated associations between greater rate/volume of intravenous (IV) fluid administration and poorer clinical outcomes. One postulated mechanism for harm from exogenous fluids is shedding of the endothelial glycocalyx (EG).

Methods

A systematic review using relevant search terms was performed using Medline, EMBASE and Cochrane databases from inception to October 2023. Included studies involved humans where the exposure was rate or volume of IV fluid administration and the outcome was EG shedding. The protocol was prospectively registered on PROSPERO: CRD42021275133.

Results

The search yielded 450 articles, with 20 articles encompassing 1960 participants included in the review. Eight studies were randomized controlled clinical tri

SUBMITTER: Sukudom S 

PROVIDER: S-EPMC10894789 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature