Does cleavage stage morphology increase the discriminatory power of prediction in blastocyst transfer outcome?

ABSTRACT:

Purpose

To evaluate the contribution of the cleavage stage morphological parameters to the prediction of blastocyst transfer outcomes.

Methods

A retrospective study was conducted on 8383 single-blastocyst transfer cycles including 2246 fresh and 6137 vitrified-warmed cycles. XGboost, LASSO, and GLM algorithms were employed to establish models for assessing the predictive value of the cleavage stage morphological parameters in transfer outcomes. Four models were developed using each algorithm: all-in model with or without day 3 morphology and embryo quality-only model with or without day 3 morphology.

Results

The live birth rate was 48.04% in the overall cohort. The AUCs of the models with the algorithm of XGboost were 0.83, 0.82, 0.63, and 0.60; with LASSO were 0.66,

SUBMITTER: Liu Z 

PROVIDER: S-EPMC10894791 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature