2% chlorhexidine gluconate aqueous versus 2% chlorhexidine gluconate in 70% isopropyl alcohol for skin disinfection prior to percutaneous central venous catheterisation: the ARCTIC randomised controlled feasibility trial.

ABSTRACT:

Objective

Catheter-related sepsis (CRS) is a major complication with significant morbidity and mortality. Evidence is lacking regarding the most appropriate antiseptic for skin disinfection before percutaneous central venous catheter (PCVC) insertion in preterm neonates. To inform the feasibility and design of a definitive randomised controlled trial (RCT) of two antiseptic formulations, we conducted the Antiseptic Randomised Controlled Trial for Insertion of Catheters (ARCTIC) feasibility study to assess catheter colonisation, sepsis, and skin morbidity.

Design

Feasibility RCT.

Setting

Two UK tertiary-level neonatal intensive care units.

Patients

Preterm infants born <34 weeks' gestation scheduled to undergo PCVC insertion.

Interventions

Skin disinfecti

SUBMITTER: Clarke P 

PROVIDER: S-EPMC10894828 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature