Impact of tumour volume and treatment delay on the outcome after linear accelerator-based fractionated stereotactic radiosurgery of uveal melanoma.

ABSTRACT:

Background/aims

Primary radiation therapy is used to treat malignant uveal melanoma (UM). We report our single-centre experience with fractionated radiosurgery (fSRS) with a linear accelerator (LINAC) after specific adaptation for small target volumes with HybridArc.

Methods

From October 2014 to January 2020, 101 patients referred to Dessau City Hospital with unilateral UM underwent fSRS with 50 Gy given in five fractions on five consecutive days. Primary endpoints were local tumour control, globe preservation, metastasis and death. Potential prognostic features were analysed. Kaplan-Meier analysis, Cox proportional hazards model and linear models were used for calculations.

Results

The median baseline tumour diameter was 10.0 mm (range, 3.0-20.0 mm), median tumour th

SUBMITTER: Sreenivasa S 

PROVIDER: S-EPMC10894830 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature