Counteracting tryptophan metabolism alterations as a new therapeutic strategy for rheumatoid arthritis.

ABSTRACT:

Objectives

Alterations in tryptophan (Trp) metabolism have been reported in inflammatory diseases, including rheumatoid arthritis (RA). However, understanding whether these alterations participate in RA development and can be considered putative therapeutic targets remains undetermined.In this study, we combined quantitative Trp metabolomics in the serum from patients with RA and corrective administration of a recombinant enzyme in experimental arthritis to address this question.

Methods

Targeted quantitative Trp metabolomics was performed on the serum from 574 previously untreated patients with RA from the ESPOIR (Etude et Suivi des POlyarthrites Indifférenciées Récentes) cohort and 98 healthy subjects. A validation cohort involved 69 established patients with RA. Dosages w

SUBMITTER: Moulin D 

PROVIDER: S-EPMC10894831 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature