Distribution and elimination kinetics of midazolam and metabolites after post-resuscitation care: a prospective observational study.

ABSTRACT: Administration of sedatives for post-resuscitation care can complicate the determination of the optimal timing to avoid inappropriate, pessimistic prognostications. This prospective study aimed to investigate the distribution and elimination kinetics of midazolam (MDZ) and its metabolites, and their association with awakening time. The concentrations of MDZ and its seven metabolites were measured immediately and at 4, 8, 12, and 24 h after the discontinuation of MDZ infusion, using liquid chromatography-tandem mass spectrometry. The area under the time-plasma concentration curve from 0 to 24 h after MDZ discontinuation (AUC_last) was calculated based on the trapezoidal rule. Of the 15 enrolled patients, seven awakened after the discontinuation of MDZ infusion. MDZ and three of it

SUBMITTER: Jeong W 

PROVIDER: S-EPMC10894853 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature