Dataset Information

Up-regulated expression of two-pore domain K⁺ channels, KCNK1 and KCNK2, is involved in the proliferation and migration of pulmonary arterial smooth muscle cells in pulmonary arterial hypertension.

ABSTRACT:

Background

Pulmonary arterial hypertension (PAH) is a severe and rare disease in the cardiopulmonary system. Its pathogenesis involves vascular remodeling of the pulmonary artery, which results in progressive increases in pulmonary arterial pressure. Chronically increased pulmonary arterial pressure causes right ventricular hypertrophy and subsequent right heart failure. Pulmonary vascular remodeling is attributed to the excessive proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs), which are induced by enhanced Ca²⁺ signaling following the up-/down-regulation of ion channel expression.

Objectives

In the present study, the functional expression of two-pore domain potassium KCNK channels was investigated in PASMCs from idiopathic PAH (IPA

SUBMITTER: Shima N

PROVIDER: S-EPMC10894933 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature

ACCESS DATA

Dataset Information

Up-regulated expression of two-pore domain K⁺ channels, KCNK1 and KCNK2, is involved in the proliferation and migration of pulmonary arterial smooth muscle cells in pulmonary arterial hypertension.

Background

Objectives

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Up-regulated expression of two-pore domain K+ channels, KCNK1 and KCNK2, is involved in the proliferation and migration of pulmonary arterial smooth muscle cells in pulmonary arterial hypertension.

Background

Objectives

OmicsDI is part of the ELIXIR infrastructure

Tweets

Up-regulated expression of two-pore domain K⁺ channels, KCNK1 and KCNK2, is involved in the proliferation and migration of pulmonary arterial smooth muscle cells in pulmonary arterial hypertension.