Exploration of potential biomarkers for early bladder cancer based on urine proteomics.

ABSTRACT:

Background

Bladder cancer is a common malignant tumor of the urinary system. The progression of the condition is associated with a poor prognosis, so it is necessary to identify new biomarkers to improve the diagnostic rate of bladder cancer.

Methods

In this study, 338 urine samples (144 bladder cancer, 123 healthy control, 32 cystitis, and 39 upper urinary tract cancer samples) were collected, among which 238 samples (discovery group) were analyzed by LC-MS. The urinary proteome characteristics of each group were compared with those of bladder cancer, and the differential proteins were defined by bioinformatics analysis. The pathways and functional enrichments were annotated. The selected proteins with the highest AUC score were used to construct a diagnostic panel. One hun

SUBMITTER: Zhou X 

PROVIDER: S-EPMC10894981 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature