Pan-immune inflammation value as a prognostic biomarker for cancer patients treated with immune checkpoint inhibitors.

ABSTRACT:

Background

Immune checkpoint inhibitors (ICIs) represent a paradigm shift in the development of cancer therapy. However, the improved efficacy of ICIs remains to be further investigated. We conducted a systematic review and meta-analysis to evaluate the pan-immunoinflammatory value (PIV) and PILE score used to predict response to ICI therapy.

Methods

We searched selected databases for studies on pan-immune inflammation values and their association with outcomes of treatment with immune checkpoint inhibitors. We used hazard ratios (HRS) and 95% confidence intervals (CI) to summarize survival outcomes. All data analyses were performed using STATA 15.0.

Results

7 studies comprising 982 patients were included in the meta-analysis. The pooled results showed that higher PIV

SUBMITTER: Kuang T 

PROVIDER: S-EPMC10895004 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature