The causal effect of two occupational factors on osteoarthritis and rheumatoid arthritis: a Mendelian randomization study.

ABSTRACT:

Background

Osteoarthritis (OA) and rheumatoid arthritis (RA) are two common types of arthritis. We conducted a two-sample Mendelian randomization (MR) study to estimate the causal effects of two common occupational factors-job involves heavy manual or physical work and job involves mainly walking or standing-on OA and RA in individuals of European ancestry.

Methods

Instruments were chosen from genome-wide association studies (GWASs) that identified independent single nucleotide polymorphisms (SNPs) robustly linked to job involves heavy manual or physical work (N = 263,615) as well as job involves mainly walking or standing (N = 263,556). Summary statistics for OA and RA were taken from the Integrative Epidemiology Unit (IEU) GWAS database; both discovery and re

SUBMITTER: Huang J 

PROVIDER: S-EPMC10895025 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature