Ketogenic diet reduces a neurobiological craving signature in inpatients with alcohol use disorder.

ABSTRACT:

Background and aims

Increasing evidence suggests that a ketogenic (high-fat, low-carbohydrate) diet (KD) intervention reduces alcohol withdrawal severity and alcohol craving in individuals with alcohol use disorder (AUD) by shifting brain energetics from glucose to ketones. We hypothesized that the KD would reduce a neurobiological craving signature when individuals undergoing alcohol detoxification treatment were exposed to alcohol cues.

Methods

We performed a secondary analysis of functional magnetic resonance data of 33 adults with an AUD who were randomized to a KD (n = 19) or a standard American diet (SA; n = 14) and underwent 3 weeks of inpatient alcohol detoxification treatment. Once per week, participants performed an alcohol cue-reactivity paradigm wit

SUBMITTER: Wiers CE 

PROVIDER: S-EPMC10895037 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature