Taxonomic and functional shifts of gut microbiome in immunoglobulin A vasculitis children and their mothers.

ABSTRACT:

Objectives

To examine the gut microbiota characteristics in children with immunoglobulin A vasculitis and their interrelationships with the host, while evaluate the vertical inheritance of microbiota in the development and progression of IgA vasculitis.

Methods

This study investigated the gut microbiome of 127 IgA vasculitis mother-child pairs and 62 matched healthy mother-child pairs, and compared the gut microbial composition of different groups. The pathway enrichment analysis evaluated potential gut microbiome-mediated pathways involved in the pathophysiology of IgA vasculitis. The Spearman correlation analysis illustrated the relationships between clinical variables and bacterial biomarkers.

Results

This study identified distinct intestinal microbiome in IgA vasc

SUBMITTER: Liang Y 

PROVIDER: S-EPMC10895042 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature