Biomarkers of systemic inflammation provide additional prognostic stratification in cancers of unknown primary.

ABSTRACT:

Background

Biomarkers of systemic inflammation have been shown to predict outcomes in patients with cancer of unknown primary (CUP). We sought to validate these findings in patients with confirmed CUP (cCUP) and explore their role alongside existing clinicopathological prognostic categories.

Patients and methods

CUP oncologist from across the United Kingdom were invited to include patients with cCUP referred to their local CUP multidisciplinary team. Patient demographics, clinical, pathological and outcome data were recorded and analysed.

Results

Data were available for 548 patients from four CUP services. 23% (n = 124) of patients met clinicopathological criteria for favourable-risk cCUP. On multivariate analysis c-reactive protein (CRP) (p < 0.001) and the Scottish

SUBMITTER: Harvey S 

PROVIDER: S-EPMC10895198 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature