Mutations of the circadian clock genes <i>Cry</i>, <i>Per,</i> or <i>Bmal1</i> have different effects on the transcribed and nontranscribed strands of cycling genes.

ABSTRACT: One important goal of circadian medicine is to apply time-of-day dosing to improve the efficacy of chemotherapy. However, limited knowledge of how the circadian clock regulates DNA repair presents a challenge to mechanism-based clinical application. We studied time-series genome-wide nucleotide excision repair in liver and kidney of wild type and three different clock mutant genotypes (Cry1^-/-Cry2^-/-, Per1^-/-Per2^-/-, and Bmal1^-/-). Rhythmic repair on the nontranscribed strand was lost in all three clock mutants. Conversely, rhythmic repair of hundreds of genes on the transcribed strand (TSs) persisted in the livers of Cry1^-/-Cry2^-/- and Per1^-/-P

SUBMITTER: Yang Y 

PROVIDER: S-EPMC10895256 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature