Immunohistochemical examination of the utero-placental interface of cows on days 21, 31, 40, and 67 of gestation.

ABSTRACT: What we understand about early stages of placentation in cattle is based on an elegant series of electron microscopic images that provide exquisite detail, but limited appreciation for the microanatomy across the utero-placental interface. In order to achieve a global perspective on the histology of bovine placentation during critical early stages of gestation, i.e., days 21, 31, 40, and 67, we performed immunohistochemistry to detect cell-specific expression of pregnancy-associated glycoprotein (PAG), cytokeratin, epithelial (E)-cadherin, and serine hydroxymethyltransferase 2 (SHMT2) at the intact utero-placental interface. Key findings from the immunohistochemical analyses are that there are: (1) PAG-positive cells with a single nucleus within the uterine luminal epithelial (LE) cells; (

SUBMITTER: Seo H 

PROVIDER: S-EPMC10895283 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature