Decreased NSD2 impairs stromal cell proliferation in human endometrium via reprogramming H3K36me2.

ABSTRACT:

In brief

The proliferation of the endometrium is regulated by histone methylation. This study shows that decreased NSD2 impairs proliferative-phase endometrial stromal cell proliferation in patients with recurrent implantation failure via epigenetic reprogramming of H3K36me2 methylation on the promoter region of MCM7.

Abstract

Recurrent implantation failure (RIF) is a formidable challenge in assisted reproductive technology because of its unclear molecular mechanism. Impaired human endometrial stromal cell (HESC) proliferation disrupts the rhythm of the menstrual cycle, resulting in devastating disorders between the embryo and the endometrium. The molecular function of histone methylation enzymes in modulating HESC proliferation remains largely uncharacterized. Herein, we fo

SUBMITTER: Qin CM 

PROVIDER: S-EPMC10895284 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature