Factors associated with disease control failure in acromegaly patients treated with pegvisomant: an ACROSTUDY analysis.

ABSTRACT:

Purpose

The aim of this study was to examine the probability of achieving acromegaly disease control according to several patient-, disease- and treatment-related factors longitudinally.

Methods

We analyzed data from ACROSTUDY, an open-label, noninterventional, post-marketing safety surveillance study conducted in 15 countries. A total of 1546 patients with acromegaly and treated with pegvisomant, with available information on baseline IGF-1 level, were included. Factors influencing IGF-1 control were assessed up to 10 years of follow-up by mixed-effects logistic regression models, taking into account changing values of covariates at baseline and at yearly visits. Twenty-eight anthropometric, clinical and treatment-related covariates were examined through univariate and mult

SUBMITTER: Giampietro A 

PROVIDER: S-EPMC10895310 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature