Adaptive nonequilibrium design of actin-based metamaterials: Fundamental and practical limits of control.

ABSTRACT: The adaptive and surprising emergent properties of biological materials self-assembled in far-from-equilibrium environments serve as an inspiration for efforts to design nanomaterials. In particular, controlling the conditions of self-assembly can modulate material properties, but there is no systematic understanding of either how to parameterize external control or how controllable a given material can be. Here, we demonstrate that branched actin networks can be encoded with metamaterial properties by dynamically controlling the applied force under which they grow and that the protocols can be selected using multi-task reinforcement learning. These actin networks have tunable responses over a large dynamic range depending on the chosen external protocol, providing a pathway to encoding "m

SUBMITTER: Chennakesavalu S 

PROVIDER: S-EPMC10895351 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature