The central renin-angiotensin system: A genetic pathway, functional decoding, and selective target engagement characterization in humans.

ABSTRACT: Accumulating evidence suggests that the brain renin angiotensin system (RAS) plays a pivotal role in the regulation of cognition and behavior as well as in the neuropathology of neurological and mental disorders. The angiotensin II type 1 receptor (AT1R) mediates most functional and neuropathology-relevant actions associated with the central RAS. However, an overarching comprehension to guide translation and utilize the therapeutic potential of the central RAS in humans is currently lacking. We conducted a comprehensive characterization of the RAS using an innovative combination of transcriptomic gene expression mapping, image-based behavioral decoding, and pre-registered randomized controlled discovery-replication pharmacological resting-state functional magnetic resonance imaging (fMRI)

SUBMITTER: Xu T 

PROVIDER: S-EPMC10895353 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature