NAMPT‑NAD⁺ is involved in the senescence‑delaying effects of saffron in aging mice.

ABSTRACT: As the proportion of the elderly population grows rapidly, the senescence-delaying effects of Traditional Chinese Medicine is being investigated. The aim of the present study was to investigate the senescence-delaying effects of saffron in naturally aging mice. The active ingredients in an aqueous saffron extract were determined using high-performance liquid chromatography (HPLC). Mice were divided into saffron (8- and 16-months-old) and control groups (3-, 8-, and 16-months-old), and saffron extract was administered to the former groups for 8 weeks. The open field test and Barnes maze test were used to evaluate the locomotor activity, learning and memory function of the mice. The levels of inflammatory factors in the brain were determined by ELISA. In addition, the activities of acetylcho

SUBMITTER: Xiao L 

PROVIDER: S-EPMC10895469 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature