Interleukin-6 in Patients With Heart Failure and Preserved Ejection Fraction.

ABSTRACT:

Background

Interleukin (IL)-6 is a central inflammatory mediator and potential therapeutic target in heart failure (HF). Prior studies have shown that IL-6 concentrations are elevated in patients with HF, but much fewer data are available in heart failure with preserved ejection fraction (HFpEF).

Objectives

This study aims to determine how IL-6 relates to changes in cardiac function, congestion, body composition, and exercise tolerance in HFpEF.

Methods

Clinical, laboratory, body composition, exercise capacity, physiologic and health status data across 4 National Heart, Lung, and Blood Institute-sponsored trials were analyzed according to the tertiles of IL-6.

Results

IL-6 was measured in 374 patients with HFpEF. Patients with highest IL-6 levels had greater bo

SUBMITTER: Alogna A 

PROVIDER: S-EPMC10895473 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature