The causal relationship between psoriasis and chronic obstructive pulmonary disease: A bidirectional mendelian randomization study.

ABSTRACT:

Purpose

Although many studies have investigated the association between psoriasis and chronic obstructive pulmonary disease (COPD), the causal relationship between psoriasis and COPD is still unknown.

Methods

We employed bidirectional Mendelian randomization to investigate the causal relationship between psoriasis and COPD. Genetic instruments for exposure were selected from two distinct genome-wide association study databases. Single nucleotide polymorphisms associated with exposures at the genome-wide significance level (p < 5 × 10^^-8 ) and exhibiting low linkage disequilibrium (r^{^2}  < 0.001) were chosen as instrumental variables. Causality was assessed using multiple MR methods, including Inverse-Variance Weighted (IVW), MR-Egger, Weighted Median, Si

SUBMITTER: Liu M 

PROVIDER: S-EPMC10895548 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature