Exploring the molecular mechanisms of increased intensity of pyrethroid resistance in Central African population of a major malaria vector <i>Anopheles coluzzii</i>.

ABSTRACT: Molecular mechanisms driving the escalation of pyrethroid resistance in the major malaria mosquitoes of Central Africa remain largely uncharacterized, hindering effective management strategies. Here, resistance intensity and the molecular mechanisms driving it were investigated in a population of Anopheles coluzzii from northern Cameroon. High levels of pyrethroid and organochloride resistance were observed in An. coluzzii population, with no mortality for 1× permethrin; only 11% and 33% mortalities for 5× and 10× permethrin diagnostic concentrations, and <2% mortalities for deltamethrin and DDT, respectively. Moderate bendiocarb resistance (88% mortality) and full susceptibility to malathion were observed. Synergist bioassays with piperonyl butoxide recovered permethrin susc

SUBMITTER: Fadel AN 

PROVIDER: S-EPMC10895554 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature