Probing the Mechanism of Action of Bis(phenolato) Amine (ONO Donor Set) Titanium(IV) Anticancer Agents.

ABSTRACT: The need for anticancer therapies that overcome metallodrug resistance while minimizing adverse toxicities is targeted, herein, using titanium coordination complexes. Octahedral titanium(IV) trans,mer-[Ti{R¹N(CH₂-2-MeO-4-R¹-C₆H₂)₂}₂] [R¹ = Et, allyl, n-Pr, CHO, F, CH₂(morpholino), the latter from the formyl derivative; R² = Me, Et; not all combinations] are attained from Mannich reactions of commercial 2-methoxyphenols (27-74% overall yield, 2 steps). These crystalline (four X-ray structures) Ti(IV)-complexes are active against MCF-7, HCT-116, HT-29, PANC-1, and MDA-MB-468 cancer cell lines (GI₅₀ = 0.5-38 μM). Their activity and cancer selectivity (v

SUBMITTER: Musa M 

PROVIDER: S-EPMC10895680 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature