Consideration of sex as a biological variable in diabetes research across twenty years.

ABSTRACT:

Background

Sex differences exist in the risk of developing type 1 and type 2 diabetes, and in the risk of developing diabetes-associated complications. Sex differences in glucose homeostasis, islet and β cell biology, and peripheral insulin sensitivity have also been reported. Yet, we lack detailed information on the mechanisms underlying these differences, preventing the development of sex-informed therapeutic strategies for persons living with diabetes. To chart a path toward greater inclusion of biological sex as a variable in diabetes research, we first need a detailed assessment of common practices in the field.

Methods

We developed a scoring system to evaluate the inclusion of biological sex in manuscripts published in Diabetes, a journal published by the American Diab

SUBMITTER: Cherian CM 

PROVIDER: S-EPMC10895746 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature