Comprehensive machine learning-based preoperative blood features predict the prognosis for ovarian cancer.

ABSTRACT:

Purpose

Significant advancements in improving ovarian cancer (OC) outcomes have been limited over the past decade. To predict prognosis and improve outcomes of OC, we plan to develop and validate a robust prognosis signature based on blood features.

Methods

We screened age and 33 blood features from 331 OC patients. Using ten machine learning algorithms, 88 combinations were generated, from which one was selected to construct a blood risk score (BRS) according to the highest C-index in the test dataset.

Results

Stepcox (both) and Enet (alpha = 0.7) performed the best in the test dataset with a C-index of 0.711. Meanwhile, the low RBS group possessed observably prolonged survival in this model. Compared to traditional prognostic-related features such as age, stage, gra

SUBMITTER: Wu M 

PROVIDER: S-EPMC10895771 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature