Ontology highlight
ABSTRACT:
SUBMITTER: Rifat A
PROVIDER: S-EPMC10895799 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
Rifat Ali A Ossola Bernardino B Bürli Roland W RW Dawson Lee A LA Brice Nicola L NL Rowland Anna A Lizio Marina M Xu Xiao X Page Keith K Fidzinski Pawel P Onken Julia J Holtkamp Martin M Heppner Frank L FL Geiger Jörg R P JRP Madry Christian C
Journal of neuroinflammation 20240226 1
Neuroinflammation is highly influenced by microglia, particularly through activation of the NLRP3 inflammasome and subsequent release of IL-1β. Extracellular ATP is a strong activator of NLRP3 by inducing K<sup>+</sup> efflux as a key signaling event, suggesting that K<sup>+</sup>-permeable ion channels could have high therapeutic potential. In microglia, these include ATP-gated THIK-1 K<sup>+</sup> channels and P2X7 receptors, but their interactions and potential therapeutic role in the human b ...[more]