PARP inhibitor era in ovarian cancer treatment: a systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Background

Ovarian cancer is the eighth leading cause of cancer-related death among women, characterized by late diagnosis and a high relapse rate. In randomized controlled trials, we aimed to evaluate the efficacy and safety of PARP inhibitors (PARPi) in treating advanced ovarian cancer.

Methods

This review was registered on PROSPERO (CRD42021283150), included all phase II and phase III randomized controlled trials (RCTs) assessing the effect of PARPi on ovarian cancer until the 13th of April, 2022. The main outcomes were progression- free survival (PFS), overall survival (OS), and adverse events (AEs). Pooled hazard ratios (HRs), and risk ratios (RRs) were calculated with 95% confidence intervals (95% CI). The random-effects model was applied in all analyses.

Results

SUBMITTER: Baradacs I 

PROVIDER: S-EPMC10895809 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature