Lysozyme promotes renal fibrosis through the JAK/STAT3 signal pathway in diabetic nephropathy.

ABSTRACT:

Introduction

Diabetic nephropathy (DN) is a leading cause of kidney failure. Lysozyme (LYZ) is an essential component of innate immunity and exhibits antibacterial properties. However, LYZ has been reported to induce nephropathy, implying a possible association between impaired renal function and lysozyme expression.

Material and methods

Bioinformatics analysis was used to predict the hub gene associated with DN, and the differential expression of the hub gene was confirmed using a mouse model. A mouse model of streptozotocin (STZ)-induced diabetic nephropathy was established to investigate the correlation between DN and LYZ expression, and the functionality of LYZ was verified through knockdown and overexpression experiments conducted in vivo. Immunohistochemistry (I

SUBMITTER: Ren Y 

PROVIDER: S-EPMC10895955 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature