Homeodomain-only protein suppresses proliferation and contributes to differentiation- and age-related reduced CD8⁺ T cell expansion.

ABSTRACT: T cell activation is a tightly controlled process involving both positive and negative regulators. The precise mechanisms governing the negative regulators in T cell proliferation remain incompletely understood. Here, we report that homeodomain-only protein (HOPX), a homeodomain-containing protein, and its most abundant isoform HOPXb, negatively regulate activation-induced proliferation of human T cells. We found that HOPX expression progressively increased from naïve (T_N) to central memory (T_CM) to effector memory (T_EM) cells, with a notable upregulation following in vitro stimulation. Overexpression of HOPXb leads to a reduction in T_N cell proliferation while HOPX knockdown promotes proliferation of T_N

SUBMITTER: Yang Q 

PROVIDER: S-EPMC10895957 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature