Association of the MMP-3, MMP-9 and MMP-12 gene polymorphisms with COPD risk: a meta-analysis.

ABSTRACT:

Introduction

Given the evidence that the matrix metalloproteinases (MMPs) play an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD), a number of case-control studies have attempted to assess the relationship between genetic polymorphisms in MMP genes and COPD risk. However, reliable measures of these results are lacking.

Material and methods

We assessed the published evidence for association of the MMP-3, MMP-9 and MMP-12 polymorphisms with COPD risk using meta-analytic techniques. The odds ratio (OR) and 95% confidence interval (CI) were calculated for each study using fixed or random effect models.

Results

A total of 23 case-control studies were included in the meta-analysis. No significant association was observ

SUBMITTER: Zhao H 

PROVIDER: S-EPMC10895971 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature