Angelica keiskei water extract Mitigates Age-Associated Physiological Decline in Mice.

ABSTRACT:

Objective

Angelica keiskei is a medicinal and edible plant that has been reported to possess potent antioxidant properties in several in vitro models, but its effectiveness on naturally aging organisms is still lacking. This study explores the antioxidant and health-promoting effects of Angelica keiskei in naturally aging mice.

Methods

We treated 48-week-old mice with Angelica keiskei water extract (AKWE) 30 days, and measured indicators related to aging and antioxidants. In addition, we conducted network pharmacology analysis, component-target molecular docking, real-time PCR, and MTS assays to investigate relevant factors.

Results

The results indicated that administration of AKWE to mice led to decrease blood glucose levels, improve muscle fiber structure, muscle st

SUBMITTER: Liu H 

PROVIDER: S-EPMC10896161 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature