Gene network based analysis identifies a coexpression module involved in regulating plasma lipids with high-fat diet response.

ABSTRACT: Plasma lipids are modulated by gene variants and many environmental factors, including diet-associated weight gain. However, understanding how these factors jointly interact to influence molecular networks that regulate plasma lipid levels is limited. Here, we took advantage of the BXD recombinant inbred family of mice to query weight gain as an environmental stressor on plasma lipids. Coexpression networks were examined in both nonobese and obese livers, and a network was identified that specifically responded to the obesogenic diet. This obesity-associated module was significantly associated with plasma lipid levels and enriched with genes known to have functions related to inflammation and lipid homeostasis. We identified key drivers of the module, including Cidec, Cidea, Pparg, Cd36, a

SUBMITTER: Xu F 

PROVIDER: S-EPMC10896179 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature