Allostatic Load and Cognitive Function Among Urban Adults in the Healthy Aging in Neighborhoods of Diversity across the Life Span Study.

ABSTRACT:

Background

Cross-sectional studies have linked cognition to allostatic load (AL) which reflects multisystem dysregulation from life course exposure to stressors.

Objective

To examine baseline and changes in AL and their relationships with 11 cognitive function test scores, while exploring health disparities according to sex and race.

Methods

Longitudinal [Visit 1 (2004-2009) and Visit 2 (2009-2013)] data were analyzed from 2,223 Healthy Aging in Neighborhoods of Diversity across the Life Span participants. We calculated AL total score using cardiovascular, metabolic, and inflammatory risk indicators, and applied group-based trajectory modeling to define AL change.

Results

Overall and stratum-specific relationships were evaluated using mixed-effects linear regre

SUBMITTER: Beydoun HA 

PROVIDER: S-EPMC10896260 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature