Connecting genomic results for psychiatric disorders to human brain cell types and regions reveals convergence with functional connectivity.

ABSTRACT: Understanding the temporal and spatial brain locations etiological for psychiatric disorders is essential for targeted neurobiological research. Integration of genomic insights from genome-wide association studies with single-cell transcriptomics is a powerful approach although past efforts have necessarily relied on mouse atlases. Leveraging a comprehensive atlas of the adult human brain, we prioritized cell types via the enrichment of SNP-heritabilities for brain diseases, disorders, and traits, progressing from individual cell types to brain regions. Our findings highlight specific neuronal clusters significantly enriched for the SNP-heritabilities for schizophrenia, bipolar disorder, and major depressive disorder along with intelligence, education, and neuroticism. Extrapolation of cel

SUBMITTER: Yao S 

PROVIDER: S-EPMC10896415 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature