Differences in polygenic score distributions in European ancestry populations: implications for breast cancer risk prediction.

ABSTRACT: The 313-variant polygenic risk score (PRS₃₁₃) provides a promising tool for breast cancer risk prediction. However, evaluation of the PRS₃₁₃ across different European populations which could influence risk estimation has not been performed. Here, we explored the distribution of PRS₃₁₃ across European populations using genotype data from 94,072 females without breast cancer, of European-ancestry from 21 countries participating in the Breast Cancer Association Consortium (BCAC) and 225,105 female participants from the UK Biobank. The mean PRS₃₁₃ differed markedly across European countries, being highest in south-eastern Europe and lowest in north-western Europe. Using the overall European PRS₃₁₃ distribution to categorise individuals lea

SUBMITTER: Yiangou K 

PROVIDER: S-EPMC10896416 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature