Prediction of MGMT promotor methylation status in glioblastoma by contrast-enhanced T1-weighted intensity image.

ABSTRACT:

Background

The study aims to explore MRI phenotypes that predict glioblastoma's (GBM) methylation status of the promoter region of MGMT gene (pMGMT) by qualitatively assessing contrast-enhanced T1-weighted intensity images.

Methods

A total of 193 histologically and molecularly confirmed GBMs at the Kansai Network for Molecular Diagnosis of Central Nervous Tumors (KANSAI) were used as an exploratory cohort. From the Cancer Imaging Archive/Cancer Genome Atlas (TCGA) 93 patients were used as validation cohorts. "Thickened structure" was defined as the solid tumor component presenting circumferential extension or occupying >50% of the tumor volume. "Methylated contrast phenotype" was defined as indistinct enhancing circumferential border, heterogenous enhancement, or nodu

SUBMITTER: Sanada T 

PROVIDER: S-EPMC10896622 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature